Neutrophils after ATRA/Arsenic therapy

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Neutrophils after ATRA/Arsenic therapy

#00060508

Author: Girish Venkataraman, MD, MBBS
Category: Morphologic variants of normal cells > Morphologic variants of white blood cells > Neutrophil > Abnormal neutrophils > Hyposegmented neutrophil
Published Date: 02/23/2016

Hypolobate and abnormal nuclear segmentation and cytoplasmic granulation in neutrophils maturing out after arsenic/ATRA therapy for acute promyelocytic leukemia.

Such abnormal neutrophils can be seen for up to 10-14 days after initiation after therapy and pose diagnostic confusion fairly frequently.

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