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AML with inv(3)(q21q26.2)

Author:  Elizabeth L. Courville, MD; Gordana Raca, Ph D, 09/23/2015
Category: Myeloid Neoplasms and acute leukemia (WHO 2016) > Acute Myeloid Leukemia > Acute Myeloid Leukemia with recurrent genetic abnormalities > AML with inv(3)(q21q26.2) or t(3;3)(q21;q26.2); GATA2, MECOM
Published Date: 02/25/2016
     
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74 year old female with cytopenias. No prior history of chemotherapy or radiation therapy. Peripheral blood counts: WBC 2.4 with 44% blasts; 8.8 Hgb, MCV 99; Platelets 233 (WNL).

Bone Marrow Aspirate

Representative images of the bone marrow aspirate showing increased blasts (72% by aspirate differential). Dysplastic features were seen in the neutrophil and erythroid lineages. Megakaryocytes include small and hypolobated forms and forms with separated nuclear lobes

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Bone Marrow Biopsy

The trephine core is hypercellular with sheets of blasts and frequent dysplastic megakaryocytes (small, with hypolobated nuclei). 

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Cytogenetics

Cytogenetics 

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